Dr Yellapragada Lifesciences Drug discovery Network has facilities and expertise to perform all aspects of health and environmental safety testing with animals. We continue to develop new techniques in line with SOP-based systems with advances in regulatory requirements and also constantly working towards the 3R principle.
TOXICOLOGY - INVIVO
| ACUTE ORAL TOXICITY – UP AN D DOWN PROCEDURE (UDP) |
| ACUTE ORAL TOXICITY –TOXIC CLASS METHOD |
| ACUTE DERMAL TOXICITY (RAT/RABBIT) |
| ACUTE DERMAL IRRITATION IN RABBIT |
| ACUTE EYE IRRITATION IN RABBIT |
| SKIN SENSITIZATION IN GUINEA PIG: BUEHLER TEST, MAGNUSSON & KLIGMAN |
| REPEATED DOSE 28-DAY TOXICITY STUDY IN RODENTS |
| 90-DAY ORAL TOXICITY IN RODENTS |
ROUTE OF ADMINISTRATION
Oral, Dermal, Intra dermal, Subcutaneous, Intravenous, Intra peritoneal and Intramuscular
GENO-TOXICITY STUDIES
Genotoxicity testing is an important part of the hazard assessment of chemicals for regulatory purposes. To assess genotoxicity different endpoints must be taken into consideration: besides point mutations induction, a compound can induce changes in the chromosomal number or in chromosome structure.
Our OECD compliant in vitro and/or in vivo genetic toxicology tests include :
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| AMES TEST |
| GENE MUTATION TEST IN MAMMALIAN CELLS: MOUSE LYMPHOMA TEST |
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| COMET ASSAY IN PRIMARY SKIN CELLS OR MODELS |
| MICRONUCLEUS TEST IN PRIMARY SKIN CELLS OR MODELS |
ECO-TOXICOLOGY STUDIES
The impact of chemicals in the Eco-system is a regulatory requirement. The following studies are conducted to draw the eco-toxic effect of the given test item.
| ALGAE GROWTH INHIBITION TEST |
| ACUTE IMMOBILIZATION TEST (DAPHNIA SP.,) |
| ACUTE TOXICITY IN FISH |
| EARTHWORM, ACUTE TOXICITY TEST |
| ACUTE ORAL TOXICITY TEST – JAPANESE QUAIL |