IN vivo / Animal Studies
We at DR YELLAPRAGADA LIFESCIENCES provide custom-based services and solutions in IN VIVO studies. The essential drug development requires compound safety and effectiveness; we design well-planned studies along with the analysis of the required samples thereby providing a total development program and the best-in-class services thereafter. We also do the later phase trials with dosing regimens to evaluate the pharmacodynamics of the drug safety and efficacy. We have sophisticated laboratories in compliance with GLP standards to perform pharmacokinetics, pharmacodynamics, and clinical research studies.
The in vivo studies are done in various animal species, including:
- MICE
- RATS
- NON-HUMAN PRIMATES
- RABBITS
- GUINEA PIGS
CLINICAL RESEARCH
PHARMACOKINETICS
PHARMACOKINETICS
We at DR YELLAPRAGADA LIFESCIENCES offer wide range of preclinical in vivo pharmacology efficacy studies in the therapeutic areas of inflammation, pain, metabolic diseases etc. In-house bred and imported animals would be used in the studies.
INFLAMMATION AND PYROGEN
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LPS INDUCED SEPSIS MODEL IN MICE.
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ADJUVANT INDUCED ARTHRITIS MODEL IN RATS
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COLLAGEN INDUCED ARTHRITIS MODEL IN MICE
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CARRAGEENAN INDUCED PAW OEDEMA MODEL
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RAT AIR POUCH MODEL
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METABOLIC DISORDERS
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DIABETIC NEUROPATHY MODELS
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STZ AND NSTZ INDUCED DIABETES MODELS L HFD + STZ INDUCED DIABETES MODELS
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GENETICALLY MODIFIED MICE (LEPR DB/DB MICE)
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PAIN
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FORMALIN INDUCED PAIN IN RATS
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ACETIC ACID INDUCED WRITHING MODEL IN SWISS ALBINO MICE
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EVALUATION OF ANALGESIC ACTIVITY BY TAIL FLICK
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APPARATUS AND EDDY'S HOT PLATE METHODS.
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ONCOLOGY
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SUBCUTANEOUS XENOGRAFT MODELS
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ORTHOTOPIC TUMOR MODELS
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METASTATIC MODELS
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SYNGENEIC MODELS
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HOLLOW FIBRE ASSAY
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INFECTIVE
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LD50 DETERMINATION (SYSTEMIC INFECTION OR MOUSE PROTECTION MODEL)
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THIGH INFECTION MODEL
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LUNG INFECTION MODEL
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CENTRAL NERVOUS SYSTEM
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MOTOR ACTIVITY
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BEHAVIOR
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BODY TEMPERATURE
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SENSORY/ MOTOR REFLEXES
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CARDIO VASCULAR SYSTEM
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SYSTOLIC & DIASTOLIC BP
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MEAN ARTERIAL PRESSURE
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HEART RATE
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OTHER IN VIVO STUDIES
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ANTI-DIABETIC STUDIES
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ANTI – PROLIFERATIVE STUDIES
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ANTI – INFLAMMATORY STUDIES
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ANTI-CANCER STUDIES
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